Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

About Iso
Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Your impact
As Isomorphic Labs accelerates its pipeline, we are approaching a critical inflection point: developing capabilities to deliver Iso’s ambition of multiple drug candidates per year. We are looking for a highly tactical and strategic Technical Program Manager to anchor this process. You will play a pivotal role in operationalising our path to the clinic, managing the complex sequencing of our first IND submissions. You will be the bridge between our scientific breakthroughs and regulatory reality, ensuring that our data management and documentation mature from research-grade to submission-ready standards.

What you will do

• Drive non-clinical IND needs: You will manage the timeline and sequencing of late-stage discovery including CMC, DMPK, pharmacology and tox reporting to enable successful submission.
• Program Management: Create and maintain rigorous project plans that monitor sequencing in a highly detailed way. You will track dependencies across multiple workstreams and manage large budgets.
• Data Management: Play a leading role in the transition of document and data management workflows from general cloud storage to submission-ready systems.
• Cross-Functional Coordination: Act as the operational hub for interdisciplinary teams, facilitating seamless communication between scientific teams, technical operations, and regulatory consultants.
• Risk Mitigation: Proactively identify and document risks in the pre-clinical phase and devise mitigation strategies in partnership with Program Leads.
• Operational Excellence: Partner with the DDMR Leads to refine the operating model for pre-clinical development.

Skills and qualifications
Essential:

• Proven track record of managing an IND application process from late discovery/pre-clinical through to submission.
• Deep experience working at the intersection of discovery and early development.
• Experience implementing or managing regulatory-compliant document management systems.
• Experience working with external vendors and collaborators.
• Experience managing large budgets.
• Ability to be "in the weeds" managing complex schedules while providing high-level strategic input.

Nice to have:

• Scientific MSc or PhD in Biology, Chemistry, toxicology or a related discipline.
• Formal program management qualification (e.g., PMP, PRINCE2).
• Experience in a high-growth Biotech or TechBio environment.

Hybrid working
We follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in).

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition or any other basis protected by applicable law.