Role Overview
Enara Bio is seeking an experienced, detail-oriented Clinical Project Manager (CPM) to lead the operational execution of clinical trials within our growing pipeline, beginning with our first-in-human ENA101 study. Reporting to the Head of Clinical Operations, the CPM will translate clinical operations strategy into detailed study plans and drive day-to-day delivery, working closely with CROs, vendors, and cross-functional partners to ensure studies are delivered on time, within budget, and to the highest quality and compliance standards.

Location: Enara is based in Oxford, UK, and offers a flexible option for hybrid work for this position. Candidates must be able to work effectively within business hours that overlap with both UK and US East Coast teams.
Reports to: Head of Clinical Operations
Level: Manager / Senior Manager

Key Responsibilities

• Own day-to-day operational execution of assigned clinical trial(s), from start-up through close-out.
• Develop and maintain integrated project plans, timelines, risk logs, and issue trackers.
• Act as the primary operational point of contact for CROs and clinical vendors.
• Monitor and report on study milestones, enrolment, and data quality/performance metrics.
• Oversee CRO and vendor performance against contracted scope, budget, and KPIs; manage change orders.
• Coordinate cross-functional input from Regulatory, Biometrics, Safety, CMC, and QA to keep studies on track.
• Support site selection, feasibility assessment, and site activation/start-up activities.
• Manage study budgets, forecasts, and vendor invoicing/reconciliation.
• Ensure trial conduct complies with the protocol, ICH-GCP, and company SOPs.
• Oversee Trial Master File completeness and support inspection readiness.
• Escalate risks and issues to the Head of Clinical Operations with clear mitigation options.
• Limited domestic/international travel as required to support site and vendor oversight.

Qualifications and experience required

• 5+ years' experience in clinical operations/project management within biotech, pharma, or a CRO.
• Experience managing global or multi-region clinical trials; early-phase oncology experience preferred.
• Working knowledge of ICH-GCP and applicable regulatory requirements (FDA, EMA, MHRA).
• Demonstrated experience overseeing CRO and vendor performance and budgets.
• Strong organisational, budget management, and risk management skills, with close attention to detail.
• Excellent written and verbal communication; able to work cross-functionally in a fast-paced biotech setting.
• Project management certification (e.g. PMP) is a plus.

Further information
The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos: Empowerment, Courage, Humility and Growth.

We offer a competitive salary, commensurate with qualifications and experience, together with a comprehensive benefits package appropriate to the successful candidate's location.

Applicants must be legally authorised to work in the country in which they reside and where employment is intended. Successful candidates will be required to provide evidence of their right to work in accordance with local requirements. Enara Bio is an equal opportunity employer.