Job summary
We are looking for an exceptional senior research nurse to join the clinical research facility (CRF) research team. This post will provide clinical leadership for our expanding research portfolio, manage junior research delivery staff and support the team to deliver high-quality research.

You will be responsible for the management of your team's research portfolio, reviewing protocols, amendments and identifying resource implications. You will have line management responsibilities and will actively be involved with staff recruitment, training, supporting and mentoring of all team members.

Applicants must be a registered adult nurse with evidence of continuing professional development. You should have good experience in clinical research within the NHS, a strong clinical background and desire and willingness to learn and develop others. Essential skills are excellent communication and interpersonal skills, the ability to prioritise and meet tight deadlines, the ability and initiative to work independently and manage a patient caseload across a variety of research studies.

The post holder is expected to work on shift patterns necessary to ensure patient safety and timely delivery of clinical trials. Work patterns will include day shifts, regular late and some night duties and weekends as required by trial protocols.

Main duties of the job
Responsibilities will include the co-ordination of a portfolio of early phase translational clinical research, collaborating with key personnel throughout the two adult Clinical Research Facilities (CRF), to ensure continued care and support for patients and healthy volunteers involved in these clinical trials and studies. The post holder will take responsibility for supervising the safe administration of experimental therapies, and for monitoring the effects of drugs and other treatment modalities used in these trials. They may also be involved in gaining ethical approval, collecting data, interviewing and data entry.

The post holder will be expected to advocate for patients and empower them to make informed choices concerning their involvement in the clinical trials by providing advice and information.

The post holder will be involved in improvement projects to further develop the operational aspect of the CRFs. This includes attending feasibility and initiation meetings, monitoring CRF supplies and equipment, facilitating orientation and support of external staff to the CRF. Aspects of the role will include clinical tasks such as phlebotomy, analysis of blood specimens, drug administration and clinical observation.

The post holder will work with a high level of autonomy, taking delegated responsibility from Clinicians for clinical decision making, and will work closely with the Investigator and multidisciplinary staff.

About us
The postholder will interact with a wide range of internal and external stakeholders involved in the delivery of the Trial including clinicians, research and health care managers, research delivery staff and research participants. Staff within the Medical School and other relevant hospitals and Trusts, non-commercial bodies and Pharmaceutical companies and/or sponsors. The postholder will lead a research nursing team dedicated to the delivery of a clinical trial portfolio.

Details
Date posted: 28 August 2026
Pay scheme: Agenda for change
Band: Band 7
Salary: £58,133 to £65,261 a year
p.a. inc HCA
Contract: Permanent
Working pattern: Full-time
Reference number: 196-RD544D
Job locations: Cross- site- Guy's CRF and St Thomas' CRF, London, SE1 9RY, United Kingdom

Job responsibilities
The post holder will:

• Lead on participant communications and well-being issues, providing specialist advice relevant to clinical research nursing
• Be responsible for leading a research nurse team to support screening of eligible research participants including providing information and support to participants, clinical follow-up, data collection and safety reporting according to requirements
• Work with the CRF Matron to establish and maintain key strategic relationships with networks of clinicians, researchers and health service managers for effective roll-out of the trials
• Work alongside a team of trial coordinators, data managers and database developers to ensure compliance with GCP, data protection and research governance frameworks, regulations and sponsor requirements
• Support the development of training materials for clinical research staff at study sites including study specific and informed consent training and elements of GCP
• Monitor participants experience and identify important participants well-being issues
• Be a central point of contact for site staff for trial-specific procedures including support to participants, eligibility assessment, informed consent, and sample management.

Person Specification
Knowledge/Qualifications
Essential

• NMC Level One Registration - RN Adult
• Your professional knowledge acquired at degree level will be supplemented by specialist training, experience and/or short courses
• ICH GCP certificated

Skills
Essential

• Substantial experience in clinical trials, teaching and mentoring as demonstrated by your individual portfolio.
• Knowledge and understanding of current UK clinical trial regulations, good clinical practice and the Declaration of Helsinki 1996
• Experience delivering specialised programmes of care, and provide highly specialised advice for patients and healthy volunteers who are participating in clinical trials
• Experience facilitating and undertaking R&D activities as major job component and undertake research, lead clinical audit in own area.
• Knowledge and experience of handling complex relationships
• Demonstrable managerial/ team leader experience
• Experience of mentoring and developing staff
• Experience of collaborating with other agencies

Desirable

• Experience of planning and delivery of training and associated resources

Experience
Essential

• Able to provide and receive complex, sensitive information, communicating this highly sensitive information to patients using empathy and reassurance, gain cooperation where required and overcome barriers to understanding by possessing excellent communication and interpersonal skills
• Able to plan and organise complex activities and programmes, requiring formulation and adjustment as necessitated
• You will recruit to, support and develop a specialist nursing service provision
• You will have the dexterity and coordination needed for undertaking venepuncture, intramuscular, skin punch biopsies and accuracy required for e.g. intravenous injections, syringe pumps and infusions
• You will possess basic laboratory skills such as centrifugation and sample separation
• You will be able to teach/deliver core training of individual clinical trial/study protocols to junior members of staff
• Excellent communication and interpersonal skills
• Ability to work autonomously and as a member of a small team, as well as part of the wider multidisciplinary team
• Ability to set direction and lead a team of research professionals
• Ability to work across boundaries, integrating with multidisciplinary staff in relation to research trials

Desirable

• SACT accreditation

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

Applicants must have current UK professional registration. For further information please see NHS Careers website (opens in a new window).

Employer details
Employer name: Guy's and St Thomas' NHS Foundation Trust
Address: Cross- site- Guy's CRF and St Thomas' CRF, London, SE1 9RY, United Kingdom
Employer's website: Apply through our website

Employer contact details
For questions about the job, contact: CRF Matron, Nadia Castrillo, nadia.castrillomartinez2@nhs.net