About Isomorphic Labs
Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

About the Toxicology team
The Toxicology team operates at the cutting-edge intersection of preclinical development and artificial intelligence, redefining how safety is assessed from the very beginning of the drug discovery process.

Your impact
As a Research Leader (Toxicology), you will own the safety assessment strategy of specific drug discovery and development projects from inception to regulatory submission. You will guide the development of our AI predictive toxicology platform and contribute to the reduction of animal testing in drug discovery.

What you will do

• Tailor and implement project-specific safety assessment strategies with an AI-first approach to support small molecules and biologics.
• Design screening cascades and mechanistic experiments to elucidate and mitigate safety risks.
• Define regulatory safety assessment packages to support successful acceptance by regulatory agencies.
• Communicate clear integrated risk assessments and recommendations to internal stakeholders.
• Author and defend toxicology sections of regulatory documents.
• Maintain and develop close relationships with the CRO network to ensure high quality and timely data generation.

Skills and qualifications
Essential:

• PhD in Toxicology, Pharmacology, Biology, or related technical field, or equivalent industrial experience.
• 8+ years of professional experience working in a senior toxicology role within a biotech or pharma setting.
• Demonstrated experience designing, implementing and filing successful IND packages for both small molecules and biologics.
• Deep understanding of Global Regulatory Guidelines regarding safety assessment.

Nice to have:

• Board certification
• Experience with peptides and other new modalities.
• Good understanding of the application of AI/ML techniques in drug discovery.

Hybrid working
This role follows a hybrid model and requires you to come into the office 3 days a week.

Isomorphic Labs is committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition, or any other basis protected by applicable law.