Job summary
Principal Clinical Scientist in Clinical Biochemistry

We are looking for a highly motivated Clinical Scientist to join the Clinical Biochemistry team at Southmead Hospital, Bristol NHS Foundation Trust. This post offers the opportunity to develop specialist expertise in the areas of toxicology and antenatal screening within the Specialist and Manual Techniques section of the Clinical Biochemistry department. The post holder will also participate in the department's general clinical validation rota and contribute to the clinical and scientific leadership of the biochemistry automated laboratory.

Applicants must be HCPC registered as a Clinical Scientist, have an MSc or PhD in an area relevant to the discipline and have completed part 1 FRCPath. A broad range of experience in Clinical Biochemistry is essential, along with good team working and leadership skills. Previous experience in Toxicology is desirable.

The Clinical Biochemistry department is part of Severn Pathology, located at Southmead Hospital in purpose-built Pathology buildings and incorporating Blood Sciences, Genetics, Infection Sciences and Cellular Pathology. Following the formation of Bristol NHS Foundation Trust we will be working closely with colleagues across the City centre and Weston to develop fully integrated pathology services within a single organisation.

Main duties of the job
To take a leading role in managing clinical and scientific aspects of the toxicology and antenatal screening services. The toxicology service includes clinical and coronial drug testing, immunosuppressants, trace metals, iohexol clearance and cholinesterase phenotyping.

To interpret and report postmortem toxicology results and liaise with pathologists, coroners officers and staff from other toxicology laboratories.

To provide clinical and scientific input in the automated biochemistry laboratory service and contribute to the general clinical biochemistry validation rota (duty biochemist). This post also includes participation in the out-of-hours on-call rota for clinical advice.

About us
Bristol NHS Foundation Trust brings together more than 28,000 staff to deliver over 160 clinical services across thirteen hospital locations, operating from three main sites at Southmead, Bristol city centre and Weston.

With an annual turnover of £2.3 billion, we are now one of the largest NHS trusts in the United Kingdom. Our hospitals are spread across Bristol and Weston, join us and you can enjoy the very best of both worlds; city living within a stone's throw of the countryside or beside the seaside, both with easy access to all that the South West has to offer.

Bristol NHS Foundation Trust values all people as individuals. As an equal opportunities employer actively working towards a diverse workforce we aim to recruit and retain a workforce which represents the rich diversity of the local population at all levels and are committed to designing our services around the needs of individual patients and those around them. Anonymous information will be used from your application in order to ensure we're meeting our pledge.

Details
Date posted: 18 September 2026
Pay scheme: Agenda for change
Band: Band 8a
Salary: £53,755 to £60,504 a year per annum
Contract: Permanent
Working pattern: Full-time
Reference number: 339-CCS8861-BAL
Job locations: Southmead Hospital, Bristol, BS10 5NB, United Kingdom

Job responsibilities
As a Principal Clinical Scientist in Clinical Biochemistry the postholder will

• be responsible for the day-to-day management of scientific aspects of the toxicology and antenatal screening services (incorporating clinical and coronial toxicology, cholinesterase and antenatal screening for trisomies), ultimately responsible to the Consultant Clinical Scientist.
• Contribute to the clinical and scientific leadership of the automated clinical biochemistry service
• Participate in the general biochemistry clinical validation rota, providing interpretation and clinical advice in general biochemistry and endocrinology, and participate in the out-of-hours on-call rota for clinical advice.
• Interpret and report toxicology results and, in conjunction with the Consultant Clinical Scientist, produce postmortem toxicology reports for pathologists and coroners.
• Take a lead role in the laboratory provision of the antenatal screening service (fetal anomaly screening program, FASP)

Please refer to the job description for more details

Person Specification
Education and Qualifications
Essential

• First or second-class honours degree in biochemistry, chemistry or a related subject.
• Master's degree (or assessed equivalent level of knowledge) in the specialty of Clinical Biochemistry
• Satisfactory completion of a formal pre-registration scientist training programme in Clinical Biochemistry
• State Registration with the Health & Care Professions Council (HCPC) as a Clinical Scientist (Clinical Biochemistry).

Desirable

• Fellowship of the Royal College of Pathologists (FRCPath)

Knowledge, skills and abilities
Essential

• Able to use and manipulate lab computer systems and standard software packages

Experience
Essential

• To have completed post graduate training approved as appropriate for registration together with supervised in-service experience totalling a minimum of 3 years
• Experience of undertaking research and development and audit
• Extensive IT experience and knowledge of laboratory computer information systems, common software packages (Word, Excel and Sharepoint) and specialist software packages (e.g. statistical packages)

Education and Qualifications
Essential

• Evidence of progression towards FRCPath, including attainment of part 1 FRCPath

Knowledge, skills and abilities
Essential

• The post holder must be able to accurately record, analyse and interpret the results of investigations undertaken within Clinical Biochemistry
• The post holder must be able to process very complex scientific information, as is required in the specialist areas of Toxicology and antenatal screening
• The ability to lead and direct a team of staff, to ensure smooth running of the Department and achievement of goals and targets in the designated section.
• To have developed analytical (technical) skills in general and specialist clinical biochemistry techniques
• To have a good knowledge of analytical methods, quality assurance and problem solving/troubleshooting

Desirable

• Highly developed expertise and knowledge of theoretical, clinical and laboratory analytical aspects of the specialist field of Toxicology
• Highly developed expertise and knowledge of theoretical, clinical and laboratory aspects of antenatal screening for trisomies
• To have developed technical ability in specialist techniques such as tandem mass spectrometry

Experience
Essential

• To have experience as a registered clinical scientist acting at a senior level in a range of clinical biochemistry specialties
• Experience of the analysis and interpretation of all aspects of General and Endocrine Biochemistry and its application to clinical practice, such that the post holder can act as an expert within the Trust
• Experience of developing and troubleshooting new methods, for use in research projects or routine clinical biochemistry service

Desirable

• Clinical and laboratory experience within the specialist field of Toxicology

Knowledge, skills and abilities
Essential

• A thorough understanding of the basic science that underpins the speciality of Clinical Biochemistry and its application to clinical practice
• An appreciation of other pathology disciplines and diagnostic imaging to view findings in the appropriate clinical context
• Able to advise medical and nursing staff on appropriate investigations and interpretation of biochemical and metabolic processes
• Expert knowledge in a specialist area of work relevant to the role (for example toxicology or antenatal screening)
• Able to initiate and conduct Research and Development activities
• Able to conduct audits of both the laboratory and clinical service
• The ability to critically appraise new information published in the literature
• An up to date awareness of national policies affecting the NHS, Laboratory Medicine, Blood Sciences and Clinical Biochemistry in particular
• Ability to communicate complex information and interpret the significance of results back to requestors
• Good oral and written communication skills
• Able to prepare and present scientific and clinical information at meetings and provide teaching and training for laboratory staff

Personal qualities
Essential

• Ability to work independently, managing own workload and that of others within the department
• Ability to work under pressure to deadlines
• Able and confident to challenge established views
• Able to maintain self-control in difficult and challenging situations
• Able to maintain intense concentration on important tasks despite frequent interruptions
• Good interpersonal skills

Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

UK Registration
Applicants must have current UK professional registration. For further information please see NHS Careers website (opens in a new window).

Employer details
Employer name: Bristol NHS Foundation Trust
Address: Southmead Hospital, Bristol, BS10 5NB, United Kingdom
Employer's website: https://www.nbt.nhs.uk/ (Opens in a new tab)

Employer contact details
For questions about the job, contact:
Consultant Clinical Scientist
Peter Beresford
Peter.Beresford@nbt.nhs.uk
01174148415

Bristol NHS Foundation Trust is an equal opportunities employer actively working towards a diverse workforce.