Job summary
Guy's and St Thomas' NHS Foundation Trust is seeking to appoint a Clinical Research Fellow in Cystic Fibrosis (CF) to be based at the Royal Brompton Hospital.

This post offers an exciting opportunity to join our CF Clinical Trials Team which has a very active and expanding clinical trials portfolio. The post is ideally suited for a paediatric or adult respiratory trainee wishing to a) gain a full understanding of the CF clinical trials pipeline, b) become trained and experienced in all aspects of clinical trial conduct including Good Clinical Practice, Research Ethics, Informed Consent, specialised outcome measures (which may include sweat testing, nasal potential difference and lung clearance index), and 3) develop independent research of their own. Trainees with an interest in CF through experience in gastroenterology, endocrinology, or other CF-related complications, will also be considered. The successful candidate will work alongside the multidisciplinary team.

The post holder will focus on clinical trials and research in cystic fibrosis, including all duties relating to the successful running of clinical trials across the age range. For an appropriate candidate, there may be the opportunity to plan an independent research project for development into a higher research degree, such as a MD (Res). The post is suitable for applicants with a range of experience; the key is enthusiasm, and training in the required role will be provided.

Main duties of the job
The appointee will focus on clinical trials and research in cystic fibrosis, although there may also be opportunities for involvement in other Chronic Suppurative Lung Diseases such as bronchiectasis and primary ciliary dyskinesia. Roles include:

• Assisting the team in the identification of suitable patients to approach and assessing eligibility
• Studying for and obtaining Good Clinical Practice (GCP) Certification and Consent Training
• Attending Investigator Meetings, Initiation visits for new trials and assisting with preparation for and conduct of monitoring/ close-out visits and regulatory inspections
• Preparing for and attending monthly team review meetings
• Performing clinical assessments adhering to trial protocols
• Reviewing laboratory test results
• Reviewing and grading adverse events; communicating closely with the consultants on these
• Liaising with sponsors and Clinical Research Organisations

About us
The Royal Brompton cystic fibrosis (CF) clinical trials department comprises of clinicians, academics, allied health professionals and admin/ finance members. The Brompton adult & paediatric CF centres are made up of world leading teams carrying out global, multicentre interventional and observational studies, in both adults and children, being led by Profs Davies, Simmonds and colleagues.

Details
Date posted: 14 July 2026
Pay scheme: Hospital medical and dental staff
Grade: Doctor - other
Salary: £54,499 to £76,582 a year
Dependant on grade/experience
Contract: Fixed term
Duration: 12 months
Working pattern: Part-time
Reference number: 196-MED5247
Job locations: Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom

Job responsibilities
Clinical/research
The appointee will have an opportunity to gain experience of adult and paediatric respiratory medicine by attending clinics and ward rounds on a supernumerary basis. They will also have the opportunity to develop their own research/quality improvement projects and contribute to other research within the department. For post-holders undertaking such activities, we will support abstract submissions to national and international conferences for further exposure to CF related research.

On Call
None; there may be opportunities for ad hoc cover of absences to be provided by a suitable qualified and experienced post-holder (optional).

Education and Training
Both Adult and Paediatric departments have regular teaching activities which the Fellow would be encouraged to attend. There are weekly respiratory seminars run through the Respiratory Clinical Research Facility.

The National Heart and Lung Institute has excellent facilities for studying and an extensive library with all the current journals and textbooks. The National Heart and Lung Institute is part of Imperial College, which greatly enhances the facilities available for studying and research.

Numerous postgraduate courses are held in the National Heart and Lung Institute and the CF Department takes an active part. Postgraduate students are attached to the Department and receive tutorials and ward rounds from members of the Department.

GMC Registration
You are required to be fully registered with the General Medical Council and to produce such evidence as may be requested.

Person Specification
EDUCATION & QUALIFICATIONS
Essential

• MBBS or equivalent

Desirable

• GCP
• MRCP or MRCPCH

EXPERIENCE & KNOWLEDGE
Essential

• Adult or paediatric respiratory medicine
• Cystic Fibrosis

Desirable

• Clinical experience in paediatric medicine

SKILLS & ABILITIES - CLINICAL
Essential

• Technical and clinical skills required for adult or paediatric respiratory medicine
• Shows an approach based on critical enquiry and evidence based medicine
• Ability to organise self and others
• Understanding of Informed Consent principles

Desirable

• ALS/PALS/APLS

SKILLS & ABILITIES - RESEARCH
Essential

• Interest in, and an ability to initiate & conduct research
• Attention to detail and meticulous record keeping

Desirable

• Published research
• Involvement in clinical trials

PERSONAL QUALITIES
Essential

• Builds a strong and effective relationship with patients, their parents and families and colleagues and gain in their confidence and trust
• Is able to cope with pressure as well as adapt to constant change and new demands
• Demonstrates honesty, commitment, and integrity

OTHER REQUIREMENTS
Essential

• Registration with GMC

Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

UK Registration
Applicants must have current UK professional registration. For further information please see NHS Careers website (opens in a new window).

Employer details
Employer name: Guy's and St Thomas' NHS Foundation Trust
Address: Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom
Employer's website: Apply through our website